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Heparin Lithium Salt CAS 9045-22-1 High Quality Blood Anticoagulant1
AdditiveHeparin Lithium SaltBlood Vessel Additives
Hubei New Desheng Material Technology Co., Ltd
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Product Description Packaging Specification : 10g/bottle,20g/bottle,50g/bottleBasic Information AppearanceWhite crystal powderPlace of OriginEzhou City, Hubei ProvinceSolubleWater: 125 mg/mLDissolutionEasily soluble in waterTiter150IU/mgMain useUsed as an external anticoagulant for bloodHeparin lithium is a chemical substance with a white to almost white powder appearance. There was no statistically significant difference in the detection results of TP, ASO, UA, ALT, Mg, Cl, TC, CRP between heparin lithium anticoagulant plasma and serum (P>0.05). There was a statistically significant difference in the detection results of HBD, LDH, and TChemicalbookBA between heparin lithium anticoagulant plasma and serum (P<0.05). Therefore, except for HBD, LDH, and TBA, the correlation between heparin lithium anticoagulant plasma and serum is good. Therefore, the feasibility of using heparin lithium anticoagulant plasma instead of serum in daily life testing is high, and it can be used as an important detection method. Preparation of heparin lithium1. Crude heparin enzymatic hydrolysis: Dissolve crude heparin sodium, adjust the pH value to 7.5-9.0, raise the temperature to 50-55 oC, add heparin enzyme to hydrolyze pancreatic enzyme, keep it for 4-5 hours, adjust the pH value to 9.0-11, raise the temperature to 85 oC~90 oC, cool, filter to remove sediment, precipitate the filtrate with ethanol, and collect sediment (A);2. Deproteinization: Dissolve the precipitate (A) obtained in step 1 with water, stir, adjust the pH to 9-11, add protein coagulant, stir, let stand, filter to remove the precipitate, collect the filtrate (D), adjust the pH of the filtrate (D) to 11-13, stir, let stand, filter to remove the precipitate, collect the filtrate (E), adjust the pH of the filtrate (E) to neutral, precipitate with ethanol, and collect the precipitate (ChemicalbookB);3. Oxidative decolorization: Dissolve the precipitate (B) obtained in step 2 in water, oxidize it with hydrogen peroxide for 24-48 hours, adjust the pH to 10.5-11.5, filter to remove the precipitate, collect the filtrate (F), adjust the pH of the filtrate (F) to 6.5-7.5, precipitate with ethanol, and collect the precipitate (C);4. Resin exchange: Dissolve the precipitate (C) obtained in step 3 with water, add LiCl, stir for dissolution, exchange ions through a resin column, collect the effluent from the column, and obtain a heparin lithium solution;5. Precipitation, dehydration, and drying: Filter the heparin lithium solution obtained in step 4, precipitate with ethanol, collect the precipitate (G), dehydrate the precipitate (G), and then vacuum dry and crush to obtain a high-quality heparin lithium product. Physical and chemical propertiesAlthough sodium and lithium are both alkali metals, lithium is composed of two stable isotopes Li6 and Li7. The conductivity of Li/10E6/cm: 0.108, the number of nuclear charges 3, and the extranuclear electron layer 1. Lithium has small density and viscosity, while Li7 has the advantage of small neutron capture area, which is only 6.2% of sodium. Lithium has fewer electrons and is relatively stable, so it is slower to combine with PLT than heparin sodium. The conductivity of sodium/10E6/cm: 0.21, nuclear charge number 11, and outer electron layer 6. From the comparison of these three values of the two elements, lithium has more stable chemical properties than sodium. Sodium has more nuclear charges and aggregates more quickly with negatively charged PLTs than heparin lithium. Full series of blood collection additives produced by Desheng Order numberProduct nameCAS Number1Serum Separating Gel /2Sodium Heparin 9041-08-13Lithium Heparin 9045-22-14EDTA K2 25102-12-95EDTA K3 65501-24-86EDTA Na2 6381-92-67Blood Clot Activation /8Blood Clot powder /9Water Soluble Silicone Release Agent /10High effective Silicone release agent /11Potassium oxalate monohydrate 6487-48-512Trisodium citrate dihydrate 6132-04-3 Company IntroductionHubei New Desheng Material Technology Co., Ltd. specializes in the production of blood collection tube additives, chemiluminescent reagents, biological buffers, chromogenic substrates, enzyme preparations, antigen antibodies and other biochemical reagents. Founded in 2005, Desheng has a professional R&D team and advanced production equipment!
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