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Factory Supply Dihexa CAS 1401708-83-5 as Brain Health Supplements1
BiochemicalDihexa (1401708-83-5)CAS 1401708-83-5
Shanghai Worldyang Chemical Co., Ltd.
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Product Description Product Name: DihexaCAS Number: 1401708-83-5Appearance: White PowderPurity: 99%Product Description:Dihexa (PNB-0408) is a synthetic oligopeptide and angiotensin IV analog with remarkable bioactivity, including oral availability and blood-brain barrier permeability. It demonstrates high-affinity binding to hepatocyte growth factor (HGF) with a dissociation constant (Kd) of 65 pM, significantly enhancing HGF's activity on its receptor, c-Met. Preclinical studies have shown Dihexa's potential in improving cognitive function and exhibiting antipsychotic effects, making it a promising candidate for Alzheimer's disease research.Biological Activity:Target Affinity: High-affinity binding to HGF (Kd: 65 pM).Mechanism: Enhances c-Met activation through HGF-dependent mechanisms, promoting synaptogenesis and spinogenesis in hippocampal neurons.In Vitro Studies:Augments HGF-dependent cell scattering and c-Met phosphorylation.Effectively inhibits HGF dimerization at 1 μM.In Vivo Studies:Long circulating half-life.Reverses scopolamine-dependent spatial learning deficits.Improves spatial learning in aged rats and induces hippocampal spinogenesis.Applications:Neurological Research: Investigated as a potential therapeutic agent for Alzheimer's disease and other cognitive disorders.Antipsychotic Development: Evaluated for its role in improving cognitive function and neuroplasticity.Cellular Studies: Ideal for research on HGF signaling pathways, synaptic formation, and neuronal development.Physical and Chemical Properties:Appearance: White PowderPurity (HPLC): ≥98.0%Acetate Content: 5.0%-12.0%Moisture Content: ≤8.0%Peptide Content: ≥80.0%Amino Acid Composition Analysis: ≤±10%Storage Information:Conditions: Hygroscopic; store in a refrigerator under an inert atmosphere to maintain stability.Features:High Purity: Ensures reliability in research applications.Blood-Brain Barrier Permeable: Suitable for neurological studies requiring CNS activity.Procognitive Activity: Potential for therapeutic exploration in neurodegenerative diseases.For further information or to discuss specific requirements, please contact us.
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