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21679-14-1 Fludarabine Direct Factory Price1
Pharmaceutical ChemicalsFludarabine21679-14-1
QINGDAO ASPIRIT CHEMICAL CO., LTD.
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Product Description Product Description Melting point 265-268°Calpha D25 +17 ±2.5° (c = 0.1 in ethanol)Boiling point 747.3±70.0 °C(Predicted)density 2.17±0.1 g/cm3(Predicted)storage temp. 2-8°Csolubility DMF: 20 mg/mL, clear, faintly yellowform Powderpka13.05±0.70(Predicted)color White to Pale YellowWater Solubility Soluble in DMF, DMSO, methanol or ethanol. Sparingly soluble in waterMerck 13,4152BRN 1225932Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.InChIInChI=1/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/s3InChIKeyHBUBKKRHXORPQB-VOSPVXAENA-NSMILESC12N=C(N=C(N)C=1N=CN2[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1)F |&1:10,11,13,15,r|CAS DataBase Reference21679-14-1(CAS DataBase Reference)Fludarabine (21679-14-1) is a synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.1 In cells fludarabine accumulates as its 5'-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate.2 F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase.2 A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation.3 Immunosuppressive effects are mediated via inhibition of TNFa-stimulated production of IL-2 and IFN-g through inactivation of NFkB.4 Antagonist at adenosine A1 receptors.5 Packaging & Shipping Packing : 200kg/drum Delivery: In stock products are normally shipping within 3 working days. For rush delivery, please contact our sales team for particular arrangement.Shipping:We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.Shipping details & shipping documents will be provided and sent by email.We keep tracking the shippment until clients well received.After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficientlyCompany Profile
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