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Pharmaceutical Raw Powder Tetracaine Hydrochloride Powder CAS No. 136-47-01
Pharmaceutical IntermediateTetracaine HClTetracaine
Xi'an Frazer Biotech Co., Ltd.
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Product Description Pharmaceutical Raw Powder Tetracaine Hydrochloride Powder CAS NO. 136-47-0SpecificationTest ItemsSpecificationTest ResultsAppearancewhite crystalline powderconfirmIdentificationABC in PassconfirmSolubilityVery soluble in water, soluble in Alcohol; insoluble in Ether and BenzeneconfirmUSP Reference standardsUSP Tetracaine Hydrochloride RS,USP Endotoxin RS.confirmMelting point145~150 degree146.0~147.5 degreeChromatographic purityIn PassconfirmRelated substanceNot more than the reference solution 0.05%confirmHeavy metals≤10ppmconfirmPH4.5-6.55.8Residue on ignition≤0.10%0.05%Loss on Drying≤ 0.5%0.19%Assay98.0 -101.0%100.1%What is Tetracaine ?Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount Function and Application of Tetracaine Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
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