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Fitness Purity Raw Retatrutide Peptide Powder Retatrutide1
Pharmaceutical IntermediateRetatrutideRetatrutide Peptide
Xi'an Sase Biotechnology Co., Ltd
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Product DescriptionFitness Purity Raw Retatrutide Peptide Powder RetatrutideProduct DescriptionProduct DetailsProduct NameRetatrutideAppearanceWhite powderCAS2381089-83-2MF0MW0Characterization of Retatrutide (CAS: 2381089-83-2)Retatrutide is a novel, investigational peptide therapeutic agent with a complex molecular structure designed for targeted metabolic modulation. This synthetic peptide features a carefully engineered sequence of 31 amino acids with multiple strategic modifications, including unnatural amino acid substitutions and side-chain alterations that enhance its stability and receptor binding affinity. The compound presents as a white to off-white lyophilized powder with a molecular weight of approximately 3.5 kDa and demonstrates limited solubility in aqueous solutions at neutral pH but excellent solubility in mildly acidic buffers. Its tertiary structure is stabilized by three intramolecular disulfide bridges that create a stable core conformation, critical for maintaining biological activity. Retatrutide is highly hygroscopic and requires storage at -20°C in sealed containers under inert atmosphere to prevent degradation. Analytical characterization by LC-MS shows a predominant peak at m/z 3498.7 [M+H]+ with ≥95% purity by HPLC-UV at 214 nm. The peptide's circular dichroism spectrum reveals characteristic α-helical content between 208-222 nm, while its fluorescence emission spectrum shows maximum tryptophan emission at 350 nm when excited at 280 nm. Stability studies indicate the compound maintains >90% potency for 24 months when stored properly, though it is sensitive to oxidation and protease degradation in solution. Quality specifications require control of related substances including deletion sequences (≤1.5%), oxidation products (≤2.0%), and dimerization products (≤3.0%), with total impurities not exceeding 5.0%.Application&FunctionFunctions and Applications of RetatrutideRetatrutide functions as a multi-receptor agonist with potent activity at GLP-1, GIP, and glucagon receptors, creating a unique trifunctional pharmacological profile for metabolic regulation. Its primary mechanism involves simultaneous activation of these receptors in pancreatic β-cells and peripheral tissues, leading to enhanced glucose-dependent secretion, improved sensitivity, and reduced hepatic glucose production. Current clinical development focuses on its application for type 2 diabetes mellitus and obesity, where phase 2 trials have demonstrated unprecedented efficacy in both glycemic control (HbA1c reductions up to 2.4%) and weight loss (up to 24% body weight reduction). The compound's extended half-life of approximately 120 hours in humans allows for once-weekly subcutaneous administration, significantly improving patient compliance compared to daily therapies. Beyond metabolic disorders, preclinical studies suggest potential applications in non-alcoholic steatohepatitis (NASH) and cardiovascular risk reduction through its pleiotropic effects on lipid metabolism and inflammation. Specialized formulations using proprietary delivery technologies are being developed to optimize its pharmacokinetic profile and minimize injection-site reactions. As a first-in-class triple agonist, Retatrutide represents a paradigm shift in metabolic disease treatment, with ongoing research exploring its potential in rare metabolic disorders and age-related metabolic dysfunction. Its development underscores the importance of polypharmacology in addressing complex metabolic pathways, though long-term safety monitoring remains essential as the compound progresses through late-stage clinical trials.Specification
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