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Best Selling Reliable Quality Raw Material 99% Powder CAS 302-79-4 Vitamin a Acid/Tretinoin/Retinoic Acid for Skincare1
Organic ChemicalsTretinoin SkincareMaterial Tretinoin
Suzhou Greenway Biotech Co., Ltd.
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Product Description Product NameRetinoic AcidOther NamesVitamin A Acid/Tretinion/TretinoinCAS No.302-79-4Molecular FormulaC20H28O2Molecular Weight300.44AppearanceYellow PowderAssay99%GradeCosmetic&Pharmaceutical GradeBrand NameGreenwayProduct Introduction:Tretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel It is also used to treat acute promyelocytic leukemia. It is also available as a generic. Its success in treating acute promyelocytic leukemia was a major breakthrough in the treatment of this type of leukemia.It works in APL because the majority of cases involve a chromosomal translocation of chromosomes 15 and 17, which causes genetic fusion of the retinoic acid receptor gene to the promyelocytic leukemia gene. This fusion PML-RAR protein is responsible for preventing immature myeloid cells from differentiating into more mature cells. This block in differentiation is thought to cause leukemia. ATRA acts on PML-RAR to lift this block, causing the immature promyelocytes to differentiate to normal mature blood cells thus decreasing promyelocytes.
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