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Antidepressant CAS 30123-17-2 Tianeptine Sodium Salt1
Pharmaceutical IntermediateTianeptine SodiumTianeptine Sodium Price
Shaanxi Zebrago Industrial Co., Limited
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Product Description Product Name:Tianeptine Sodium SaltCAS:30123-17-2MF :C21H24ClN2NaO4SGrade Standard :Pharmaceutical gradeSpecification:98%minAppearance:Off- white to white powder Tianeptine Sodium is a drug used for treating major depressive episodes (mild, moderate, or severe). It has structural similarities to the tricyclic antidepressants, but it has different pharmacological properties. Tianeptine is a selective serotonin reuptake enhancer (SSRE), opposite to the action of SSRIs. One review points to the cancellative effects of tianeptine and fluoxetine coadministration on serotonin reuptake. Another suggests that long-term administration of tianeptine has no effect on serotonin pathways. Tianeptine enhances the extracellular concentration of dopamine in the nucleus accumbens and modulates the D2 and D3 dopamine receptors. There is also action on the NMDA and AMPA receptors Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).Product NameTianeptine SodiumBatch NumberZ20180901Production Date2018.9. 3Batch Quantity24000GAnalysis Date2018.9. 4Expiry Date2020.9. 2Certificate Date2018.9. 15ItemTest StandardTesting ResultAssayNot less than (NLT) 99.5% 99.9%THNot detectedUndetectedAssayMethod HPLC calculated on the anhydrous basis limit of quotation (LOQ) 0.8ppmAppearanceWhite powderWhite powderIdentificationIn the recorded chromatograms under the determination of the substance, retention time of the main peak of the solution should be consistent with the retention of time of the main peak of the reference solutionCompliesMelting Point65~66oC65.5oCLoss on DryingNMT 1.0%0.21%Residual solventsEthanol NMT 400ppmHeptane NMT 400ppm1.92ppm256.0ppmHeavy MentalNMT 20ppmCompliesMicrobial Limite TestMethod: Plate Counting Total aerobic bacteria countNMT 1000cfu/gCompliesCombined molds and yeastNMT 100cfu/gCompliesE. ColiNot detacted per gramCompliesSalmanellaNot detacted per 10 gramCompliesConclusion: Conform the testing result is qualifiedStorage: Closed container. Dry & cool. Keep away from moisture &strong lightShelf life: 24 Months
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