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CAS: 70288-86-7 Veterinary Medicine Antiparasitic Drug Ivermectin1
Pharmaceutical IntermediateIvermectin70288-86-7
Xi'an Harmonious Natural Biotechnology Co., Ltd.
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Product Description CAS: 70288-86-7 Veterinary Medicine Antiparasitic drug Ivermectin Product NameIvermectinCAS70288-86-7Molecular formulaC48H74O14Molecular weight875.09300GradePharmaceutical GradeColorWhite powderPurity99%Shelf life2 yearsThe Introductction of Ivermectin: Ivermectin is widely used in cattle, sheep, horses, pigs, gastrointestinal nematodes, lung nematodes and parasitic arthropod,canine intestinal nematodes, ear mites, scabies mites, silk worm and microfilariae, gastrointestinal nematodes and external parasites and poultry. This product belong to the broad-spectrum resistant parasites.Ivermectin for a variety of most of the life cycle of nematodes (but not all nematodes) role; For dish tail filarial microfilariaeeffectively, but for adult worms; For only in intestinal fecal round worms are also effective.Ivermectin has the selective inhibitory effect, with no spinal nerve cells and muscle cells in the animal glutamic acid ion channels of the valve is the high binding affinity, leading to the proliferation of the chloride ion permeability of cell membrane, cause nerve cells or muscle cells hyperpolarization, parasites paralysis or death. The Application & Function of Ivermectin: 1. Ivermectin is the derivatives of abamectin. Ivermectin belongs to semisynthetic broad-spectrum resistant parasites.2. Ivermectin has effect for most of the various life cycle nematodes.3. Ivermectin has effect for the microfilaria of onchocerca volvulus,but it does not has effect for the adult onchocerca volvulus.4. Ivermectin has effect for dung round worms that is only stay in intestinal tract.5. Ivermectin has selective inhibition.6. Ivermectin can not go through the blood brain barrier of humanbeings. In veterinary medicine ivermectin powder is used against many intestinal worms (but not tapeworms), most mites, and some lice. Despite this, it is not effective for eliminating ticks, flies, flukes, or fleas. It is effective against larval heartworms, but not against adult heartworms, though it may shorten their lives. The dose of the medicine must be very accurately measured as it is very toxic in over-dosage.It is sometimes administered in combination with other medications to treat a broad spectrum of animal parasites. Some dog breeds (especially the Rough Collie, the Smooth Collie, the Shetland Sheepdog, and the Australian Shepherd), though, have a high incidence of a certain mutation within the MDR1 gene (coding for P-glycoprotein); affected animals are particularly sensitive to the toxic effects of ivermectin.Clinical evidence suggests kittens are susceptible to ivermectin toxicity. A 0.01% ivermectin topical preparation for treating ear mites in cats (Acarexx) is available.Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin. Use in turtles is particularly contraindicated. Other Name of Ivermectin: IVERMECTINHCL;IvermectinEP2000;IVERMECTINNOTLESSTHAN93.0%OF22,23-DIHY-DROAVERMECTINB1A,ANDNOTLESSTHAN97.0%OF22,23-DIChemicalbookHY-DROAVERMECTINB1(B1A+B1B);IVERMECTINEP(CRMSTANDARD);IVERMECTINUSP(CRMSTANDARD);IvermectineEp2000;IVOMEC;IVERMECTIN TestsSpecificationResultsAppearanceWhite or yellowish-white crystalline powder, slightly hygroscopic.Yellowish-white crystalline powder, slight hygroscopic.SolubilityPractically insoluble in water, soluble in alcohol.QualifiedIdentificationIRCorresponds to that of CRS standardQualifiedHPLCThe retention time for H2Bla and H2Blb in the chromatogram obtained with the test solution corresponds to those of standard preparationQualifiedAppearance of solutionClear and not more intensely colored than BY?ClearSpecific optical rotation (anhydrous and solvent-free substance), °-20--17-17.9Related substances (%)Individual impurity(RRT 1.3-1.5)≤2.5I-l:<0.05 K:2.1Any other impurity ≤ 1C:0.06 A:0.57J:0.14 H:0.39 D:<0.05 F:<0.05E:0.36 1-2:0.19Total ≤53.8Disregard limit: 0.05Ethanol and Formamide (%)Ethanol ≤5.03.9Formamide≤3.02.5Catalyst (ug/g)≤1<1Water (%)≤1.00.26Sulphated ash (%)≤0.10.07Heavy Metal (%)≤0.002<0.002Assay (%) (HPLC, on dry basis)H2Bla/(H2Bla +H2Blb)≥90.097.795.0≤H2Bla +H2Blb≤ 102.096.7ConclusionComplies with the requirements of EP10.0
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